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Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. In confluent cultures of MCF7 or MDCK cells, stably expressed EGFP-E-cadherin was rapidly recycled with spatially uniform kinetics (50 s in MCF7 and 4 min in MDCK). Clinical studies demonstrate that poor sleep quality is associated with increased frequency of drug use and relapse.

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